PT - JOURNAL ARTICLE AU - Lam, Mei Ting AU - Li, Hang Wun Raymond AU - Wong, Ching Yin Grace AU - Yeung, William Shu Biu AU - Ho, Pak Chung AU - Ng, Ernest Hung Yu TI - Women’s age and total motile normal morphology sperm count predict fecundability: a prospective cohort study AID - 10.1136/bmjsrh-2020-200639 DP - 2020 Oct 01 TA - BMJ Sexual & Reproductive Health PG - 279--286 VI - 46 IP - 4 4099 - http://jfprhc.bmj.com/content/46/4/279.short 4100 - http://jfprhc.bmj.com/content/46/4/279.full SO - BMJ Sex Reprod Health2020 Oct 01; 46 AB - Objective This study investigated the role of women’s age, serum anti-Müllerian hormone (AMH) level and semen parameters in predicting fecundability.Methods This was a prospective cohort study on couples attending for preconceptional health check. Occurrence of conception at 1 year after ceasing contraception and time to pregnancy were noted by telephone follow-up. The women’s age, serum AMH level and total motile normal morphology sperm count (TMNC) were compared between those who conceived and those who did not after 1 year; their independent predictive value on conception at 1 year was analysed by logistic regression. Among those conceiving within 1 year, Spearman’s correlations between time to pregnancy and the clinical parameters were studied.Results Of the 100 couples analysed, we found younger age of the women (p=0.008), higher serum AMH level (p=0.038) and higher TMNC (p=0.015) in those that conceived within 1 year. Multivariate logistic regression found that women’s age (OR 0.867, 95% CI 0.761 to 0.988, p=0.032) and TMNC (OR 1.089, 95% 1.001–1.185, p=0.047), but not serum AMH level, significantly predicted conception within 1 year. Among those that conceived within 1 year, none of the parameters analysed were correlated with time to pregnancy within 1 year.Conclusions Women’s age and TNMC are significant independent predictors of conception within 1 year. No parameter was shown to predict the time to pregnancy within 1 year. This finding can aid preconceptional counselling of couples who are planning for pregnancy.